A collection of well-written communications reporting the total synthesis of natural product target compounds.
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Sympathy for the amide bond
A paragraph by paragraph analysis of Haoxuan Wang and Sarah E. Reisman’s 2014 Angewandte Chemie communication on the enantioselective synthesis of (-)-lansai B and (+)-nocardioazines A and B.
The Ride of a Lifetime: a Fulbright Experience
My Fulbright experience during the spring and summer of 2013 in Barcelona played a transformative role in my life, both personally and professionally.
Deconstructing a JACS communication: Winkler’s Ingenol synthesis
A play-by-play of Winkler’s synthesis of (±)-Ingenol as reported in J. Am. Chem. Soc. 2002, 124, 9726-9728.
A Key to the Heart of Macrocyclic Structures
Positioning and Configuration of Key Atoms Influence the Topology of [13]-Macrodiolides. Jun Ma, Mark W. Peczuh* J. Org. Chem., 2013, 78, 7414–7422, DOI: 10.1021/jo400383g Atoms at specific “key” positions along the ring of a group of [13]-membered ring macrocycles can govern its shape, or “topology”. The driving force for the organization of the structures is […]