Resistance: How VanA Strains Get Away With It

An evaluation of the thermodynamics of binding between various ligands of Vancomycin (Part 1/2) by Matthew Guberman-Pfeffer* This post is also published on The Winnower under DOI:10.15200/winn.144060.03577 In Brief The longstanding invincibility of vancomycin (VC) – the last line of antimicrobial therapy for life-threatening Gram-positive infections – has been compromised over the past decade. The most common and […]

A Key to the Heart of Macrocyclic Structures

Positioning and Configuration of Key Atoms Influence the Topology of [13]-Macrodiolides. Jun Ma, Mark W. Peczuh* J. Org. Chem., 2013, 78, 7414–7422, DOI: 10.1021/jo400383g Atoms at specific “key” positions along the ring of a group of [13]-membered ring macrocycles can govern its shape, or “topology”. The driving force for the organization of the structures is […]