Year: 2017

Hypocrellin A, With a Twist

Some time ago my research group stumbled upon a family of macrocycles whose structure contained a somewhat uncommon stereogenic element, a plane of chirality. A plane of chirality arises when restricted rotation around a planar unit in a molecule leads to the formation of stereoisomers. The textbook example (seriously, look at Eliel) is E-cyclooctene. The […]

Still Working Toward Convergence in Total Synthesis

I was at the Natural Products and Bioactive Compounds Gordon Research Conference (GRC) last summer. During the usual free time one afternoon, there was a roundtable discussion about the challenges faced by women in science and strategies to overcome those challenges. The conversation was promoted by the GRC organization, which made sure there was an […]

How to Organize your Orgo Lecture Notebook

  With the hope of sharing best-practices for success in introductory orgo lecture, I asked an undergrad in my department (John Ovian) what he recommended. He gave me a sheet that explained how he organized his notebook and how his notebook became a valuable tool for studying. Those notes, plus some design inspiration from the […]